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At more colleges, classes on genetics get personal

IOWA CITY (AP) — Bakir Hajdarevic didn’t have to study for the most important test in a class last fall. He just had to spit — a lot.

The 19-year-old freshman at the University of Iowa took an honors seminar on personal genetics in which students had the option of sending saliva samples so a testing company could use DNA to unlock some of their most personal health and family secrets. The results would tell them how likely they were to get some forms of cancer, whether they were carriers for genetic diseases, where their ancestors came from, and a trove of other information.

The class, taught at Iowa for the first time, is part of a growing movement in higher education to tackle the rapidly advancing field of personal genetics, which is revolutionizing medicine and raising difficult ethical and privacy questions. The classes are forcing students to decide whether it is better to be ignorant or informed about possible health problems — a decision more Americans will confront as the price of genetic testing plummets and it becomes more popular.

Hajdarevic said he was eager to “find out about all the little mysteries” lurking in his DNA. Sure he was nervous that he might get bad news about cancer risks. But he said the curiosity to learn about himself — and whether he needed to take steps to improve his health — outweighed those concerns.

Similar classes have popped up on college campuses over the past three years with backing from 23andMe, which tests for about one million genetic variants possibly linked to tens of thousands of conditions and traits. The company announced in December it was cutting its price for personal genotype testing from $299 to $99.

Stanford professor Stuart Kim says his students will never forget the class when they learn whether they are sensitive to the blood-thinner Warfarin, as that knowledge could be critical if they ever suffer a stroke, because too large or small a dose could kill them. But he dreads the day when testing informs a student: That man who raised you? He’s not your biological father.

“That will happen one of these days,” he said.

He said 90 percent of the students have opted to test their own DNA rather than a random person’s, and a class survey found that students who did so retained more information.

University of Iowa professor Jeff Murray has been teaching human genetics for 25 years, and developed last fall’s class after reading about similar ones elsewhere. He talked through the pros and cons of testing with students, and spent two class periods examining 23andMe’s consent form. Murray encouraged students to consult with their parents, through their consent was not required — students were all 18 or older. Only a few opted out of the testing after they or their parents raised concerns.

“Some people just didn’t want to know if they are going to get breast cancer or Alzheimer’s,” said one of Murray’s students, Alexis Boothe, 18. “Personally, I wanted to know.”

She said she was not surprised when she learned she’s seven times more likely than the average person to develop Crohn’s disease, a bowel disorder, since it runs in her family. But now she said she can make sure not to smoke and watch her stress, two triggers. Boothe said she was amused when she learned that she shares northern European ancestors with the singer Jimmy Buffett, and when a third cousin she doesn’t know sent her a message through the company.

For Hajdarevic, one surprising result was that he may be lactose intolerant. Although he’s eaten dairy without issue his whole life, he can now monitor for symptoms that could develop later. He also learned he’s a carrier for the mild form of a rare genetic disease, Alpha 1-antitrypsin deficiency.

But overall, he says, he was relieved.

“I was kind of scared going in, like, ‘Oh my God, I might have a high risk factor for some kind of cancer’,” he said. “But knock on wood, according to the test, I don’t really have much to worry about.”

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