NORMAN, Okla. (AP) — Baker Mayfield and the Oklahoma Sooners pushed aside one last overmatched opponent.
Mayfield completed 23-of-31 passes for 342 yards and three touchdowns and ran for a score to help the No. 14 Sooners beat Iowa State 52-16.
Samaje Perine ran for 95 yards and a touchdown on 13 rushes, and Joe Mixon rushed for 88 yards and a touchdown on eight carries for Oklahoma (8-1, 5-1 Big 12, No. 15 CFP).
The Sooners have won four straight, outscoring their opponents 232-50. They have surpassed 50 points in four consecutive games for the first time since 2008.
Now, the Sooners can turn their attention to their difficult stretch run in which they face each of the Big 12’s top three teams. They are at No. 2 Baylor next week, take on No. 5 TCU on Nov. 21, and finish at No. 12 Oklahoma State Nov. 28.
Joel Lanning completed 26-of-51 passes for 260 yards and a touchdown for Iowa State (3-6, 2-4).
The Cyclones have lost four of their last five.
Oklahoma utilized a quick-strike, big-play offense that produced six touchdown drives of five or fewer plays — three in the opening quarter. After building a 21-3 first-quarter lead, the Sooners led 21-9 at halftime, then pulled away by scoring on all three of their third-quarter possessions.
The Sooners also played stifling defense, holding Iowa State to three first-half field goals and no second-half points until Lanning’s 13-yard touchdown pass to D’Vario Montgomery with 5:08 remaining.
Top running back Mike Warren, who averaged 154.3 yards rushing and 6.4 yards per carry over the previous six games, was held to just 43 yards on 18 carries.